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Image Search Results
Journal: bioRxiv
Article Title: Whole-body sorcin invalidation does not cause hypothalamic ER stress nor worsens obesity in C57BL/6 male mice fed a westernized diet
doi: 10.1101/2022.09.07.506981
Figure Lengend Snippet: (A) Representative Western (Immuno)blotting of pSTAT3 (Y705), STAT3 and Sorcin from whole protein lysate isolated from wild-type and sorcin null HEK293 cells expressing LepRb and stimulated with leptin (0-1 ng/mL) as described in methods. (B) Quantification of Western (Immuno)blotting from 3 independent experiments, showing the ratio between pSTAT3/STAT3 for cells stimulated with leptin (0-10 ng/mL); NT = non-transfected cells. Values are means ± SEM. Data were analysed for significance using 1-way ANOVA analysis with Tukey’s multiple comparisons test.
Article Snippet: HEK293 cells, seeded in 6-well plates, were transfected with 2 μg LepRb-HA plasmid, encoding full length clone DNA of
Techniques: Western Blot, Isolation, Expressing, Transfection
Journal: bioRxiv
Article Title: White adipose tissue undergoes pathological dysfunction in the TDP-43A315T mouse model of amyotrophic lateral sclerosis (ALS)
doi: 10.1101/2025.07.03.662925
Figure Lengend Snippet: (A) Concentration of leptin levels at diagnosis measured by ELISA in healthy controls and ALS subgrouped by sex. (B) Concentration of leptin levels at diagnosis in ALS and controls subgrouped by sex and disease progression: slow, normal and fast progression patients. (C) Concentration of leptin levels at diagnosis in ALS and controls subgrouped by sex and rate of progression in overweight patients. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Abbreviations: ALS, sporadic amyotrophic lateral sclerosis.
Article Snippet: Leptin plasma levels were measured using a
Techniques: Concentration Assay, Biomarker Discovery, Enzyme-linked Immunosorbent Assay